Species Human Entrez 23409 | Human Mouse Ensembl ENSG00000089163 | |
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Aliases SIRT4, SIR2L4, sirtuin 4 External IDs MGI: 1922637 HomoloGene: 8164 GeneCards: SIRT4 | ||
Gene music using protein sequence of sirt4 sirtuin 4
Sirtuin 4, also known as SIRT4, is a protein which in humans is encoded by the SIRT4 gene.
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Function
This gene encodes a member of the sirtuin family of proteins which are homologs of the Sir2 gene in budding yeast. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been fully determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
SIRT4 is a mitochondrial ADP-ribosyltransferase that inhibits mitochondrial glutamate dehydrogenase 1 activity, thereby downregulating insulin secretion in response to amino acids. It has been shown that SIRT4 regulates fatty acid oxidation and mitochondrial gene expression in liver and muscle cells.