Entrez 23678 | Ensembl ENSG00000104205 | |
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Aliases SGK3, CISK, SGK2, SGKL, serum/glucocorticoid regulated kinase family member 3 External IDs MGI: 2182368 HomoloGene: 56582 GeneCards: SGK3 | ||
Serine/threonine-protein kinase Sgk3 is an enzyme that in humans is encoded by the SGK3 gene.
Contents
Function
This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
In melanocytic cells SGK3 gene expression may be regulated by MITF.
Interactions
SGK3 has been shown to interact with GSK3B.
References
SGK3 Wikipedia(Text) CC BY-SA