Entrez 64218 | Ensembl ENSG00000196189 | |
External IDs MGI: 107560 HomoloGene: 8425 GeneCards: SEMA4A | ||
Function
SEMA4A is a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in guidance of axonal migration during neuronal development and in immune responses.[supplied by OMIM]
Clinical significance
A germline variant in SEMA4A (V78M) has been demonstrated to confer risk for colorectal cancer type X.
References
SEMA4A Wikipedia(Text) CC BY-SA