Species Human Entrez 10484 | Human Mouse Ensembl ENSG00000100934 | |
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Aliases SEC23A, CLSD, Sec23 homolog A, coat complex II component External IDs MGI: 1349635 HomoloGene: 4642 GeneCards: SEC23A | ||
Sec23 homolog A (S. cerevisiae), also known as SEC23A, is a protein which in humans is encoded by the SEC23A gene.
Contents
Function
The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It contains a gelsolin domain. It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking.
SEC23 interacts with both SEC16A and SEC16B.
Interactions
SEC23A has been shown to interact with SEC24C, Sec16A/p250 and iPLA1β/p125.
Sec23 has also been shown to interact with TRAPPⅠ, Grh1p also known as GRASP65 and Dynactin. Because they are involved in anterograde vesicle transport from ER to Golgi, Sec23 is involved in vesicle transport.