Species Human Entrez 6303 | Human Mouse Ensembl ENSG00000130066 | |
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Aliases SAT1, DC21, KFSD, KFSDX, SAT, SSAT, SSAT-1, spermidine/spermine N1-acetyltransferase 1 External IDs MGI: 98233 HomoloGene: 37716 GeneCards: SAT1 | ||
Diamine acetyltransferase 1 is an enzyme that in humans is encoded by the SAT1 gene found on the X chromosome.
Contents
Function
Spermidine/spermine N(1)-acetyltransferase (SPD/SPM acetyltransferase) is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the N(1)-acetylation of spermidine and spermine and, by the successive activity of polyamine oxidase, spermine can be converted to spermidine and spermidine to putrescine.
Clinical significance
An association with Keratosis follicularis spinulosa decalvans has been suggested.
Elevated levels of RNA transcripts of SAT1 in the bloodstream have been associated with a higher risk of suicide.
References
SAT1 (gene) Wikipedia(Text) CC BY-SA