S formylglutathione hydrolase

In enzymology, a S-formylglutathione hydrolase (EC 3.1.2.12) is an enzyme that catalyzes the chemical reaction

Thus, the two substrates of this enzyme are S-formylglutathione and H₂O, whereas its two products are glutathione and formate.

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is S-formylglutathione hydrolase. This enzyme participates in methane metabolism.