Rothe or Roethe is a surname. Notable people with the surname include:
Utz Rothe, Austrian artist
Bendt Rothe, Danish actor
David Rothe, Irish Roman Catholic bishop
Johannes Rothe, (1628-1702), prophetic preacher and Fifth Monarchist.
Heinrich August Rothe (1773–1842), German mathematician
Mechtild Rothe (1947), German politician
Richard Rothe (1799–1867), German theologian
Richard Roethe (1865–1944), German military officer
Sjur Røthe (1988), Norwegian cross-country skier
Edward J. Roethe, American politician
Henry Edgar Roethe (1866–1939), American politician
Rothé, a form of cattle in various roleplaying games