ATC code L03AX02 (WHO) CAS Number 84088-42-6 ChemSpider 10619239 Molar mass 308.331 g/mol | Biological half-life 26-42 hours PubChem CID 55197 UNII 372T2944C0 | |
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How to pronounce roquinimex
Roquinimex (Linomide) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity. It also inhibits angiogenesis and reduces the secretion of TNF alpha.
Contents
Roquinimex has been investigated as a treatment for some cancers (including as adjuvant therapy after bone marrow transplantation in acute leukemia) and autoimmune diseases, such as multiple sclerosis and recent-onset type I diabetes. Several trials have been terminated due to serious cardiovascular toxicity.
Synthesis
Ethyl 2-(methylamino)benzoate is condensed with ethyl malonate. Amine-ester ineterchange of that compound with N-methylaniline results in formation of the amide roquinimex.
References
Roquinimex Wikipedia(Text) CC BY-SA