Roque is a surname. Notable persons with that surname include:
Ademir Roque Kaefer (born 1960), Brazilian football playerAlphonse Roque-Ferrier (1844-1907), French philologist.Ana Roque de Duprey (1853–1933), Puerto Rican educator and suffragistBruno Roque de Sousa (born 1989), Brazilian football playerCarlos Roque (1936–2006), Portuguese comics artistChristine Roque (born 1965) French singerFelipe Pérez Roque (born 1965), Cuban politicianFrank Roque (born 1959), American convicted murdererHélio Roque (born 1985), Portuguese football playerHorácio Roque (1944–2010), Portuguese financier and businessmanHumbert Roque Versace (1937–1965), American soldierHumberto Roque Villanueva (born 1943), Mexican politicianJacinto Roque de Sena Pereira (1784–1850), Portuguese sailorJacqueline Roque (1927–1986), French modelJoao Roque (born 1971), Angolan mixed martial arts fighterJuan Roque (born 1974), American football playerMaicon Pereira Roque (born 1988), Brazilian football playerMariano Roque Alonzo (died 1853), Paraguayan politicianMarta Beatriz Roque (born 1945), Cuban political dissidentMiki Roque (born 1988), Spanish football playerNuno Roque (born 1987), Portuguese actor and singerRafael Roque (born 1972), Dominican baseball playerRandolph Roque Calvo, American Roman Catholic bishop