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Ronald T Raines

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Nationality  USA
Fields  Chemical biology
Role  Professor
Name  Ronald Raines

Alma mater  Massachusetts Institute of Technology
Known for  Research on collagen, ribonucleases, protein chemistry, and biofuels
Notable awards  Helen Hay Whitney Fellow Searle Scholar Award Presidential Young Investigator Award Shaw Scientist Award Pfizer Award in Enzyme Chemistry, ACS Guggenheim Fellow AAAS Fellow Arthur C. Cope Scholar Award, ACS Emil Thomas Kaiser Award Royal Society of Chemistry Fellow Rao Makineni Lectureship Welch Lectureship Repligen Corporation Award in Chemistry of Biological Processes ACS Jeremy Knowles Award, RSC Humboldt Research Award Ralph F. Hirschmann Award in Peptide Chemistry, ACS
Education  Harvard University (1982–1986), West Essex High School, Massachusetts Institute of Technology
Awards  Guggenheim Fellowship for Natural Sciences, US & Canada
People also search for  Jeremy R. Knowles, Sheng Ding, Daniel M. Pinkas, Annelise E. Barron

Doctoral advisor  Jeremy R. Knowles

Ronald T. Raines is an American chemical biologist. He is the Firmenich Professor of Chemistry at the Massachusetts Institute of Technology.



Raines graduated in 1976 from West Essex High School in North Caldwell, New Jersey. He received Sc.B. degrees in chemistry and biology at the Massachusetts Institute of Technology, doing undergraduate research with Christopher T. Walsh. He earned A.M. and Ph.D. degrees in chemistry at Harvard University with Jeremy R. Knowles, the title of his doctoral thesis being Energetics of Enzymatic Catalysis: Triosephosphate Isomerase. He was a Helen Hay Whitney postdoctoral fellow in the Department of Biochemistry and Biophysics at the University of California, San Francisco with William J. Rutter. He was a member of the faculty at the University of Wisconsin–Madison from 1989 until 2017, when he joined the faculty at MIT. He was a Visiting Associate in Chemistry at Caltech in 2009.


Raines has made the following noteworthy contributions.

  • Revelation of the basis for the conformational stability of collagen, which is the most abundant protein in animals. This work led to the discovery that unappreciated chemical forces—the n→π* interaction and C5 hydrogen bond—contribute to the stability of nearly every protein. Such hyperstable collagens are in preclinical trials as wound-healing agents.
  • Discovery of how to endow an otherwise innocuous human RNA-cleaving enzyme with toxicity that is specific for cancer cells. Such a ribonuclease is in a human clinical trial as an anti-cancer agent.
  • Mechanistic Insight on cellular redox homeostasis and on imperatives for the uptake of cationic proteins and peptides by mammalian cells.
  • Invention of efficient chemical processes to synthesize proteins and to convert crude biomass into useful fuels and chemicals, and fluorogenic probes to image the uptake of molecules into living cells.
  • Raines is a founder of Quintessence Biosciences, Inc. and Hyrax Energy, Inc., and he serves on the editorial advisory boards of the journals ACS Chemical Biology; Bioconjugate Chemistry; Peptide Science; Protein Engineering, Design & Selection; and Scientific Advisory Board of the Keystone Symposia.


    Ronald T. Raines Wikipedia