Rona Nishliu was raised in her birth town Mitrovica, but had to move with her family to Pristina at the age of thirteen due the political reasons in her hometown. In 2004 she entered "Ethet e së premtës mbrëma" (The excitement of Friday night) - a similar show to Idols. She successfully passed the first rounds and entered the live shows, where she finished Top 5. After the show, she worked on Radio Blue Sky in Prishtina as a presenter.
In 2005, Rona teamed up with Vesa Luma and Teuta Kurti to enter the 43rd edition of Festivali i Këngës, for a chance to represent Albania in the 2005 Eurovision Song Contest with "Flakareshë". The trio were qualified for the final night held on December 18, 2005 but lost to Ledina Çelo who was declared the winner. The song was a Pop-Dance track, and even without winning the contest, became an instant hit on the radios.
Nishliu represented Albania in the Eurovision Song Contest 2012 in Baku, Azerbaijan after winning the national selection on December 29, 2011 with the entry "Suus". She is the first singer from Kosovo to represent Albania in the contest. Because of the Qafa e Vishës bus tragedy, RTSH deferred the first semifinal by more than two hours on May 22, resulting in low ratings during Nishliu's appearance. It did not affect Nishliu's own participation in the contest, as she got second place in the semi-final and advanced to the finals. Albania used its jury votes to vote for the other 17 countries in the semifinal, and it used the jury votes again on May 26. RTK also did not air highlights from the first semifinal due to the bus crash. She ended up winning fifth place in the final with 146 points - Albania's best result to date.
She became an Albanian citizen on 12 January 2012.
Nishliu was committed to her humanitarian work immediately after Eurovision. She became a member of a project called "Bonu cool, mos bjer shpullë" (Be cool, don't slap!), a project who raises gender awareness. She released a song especially for this occasion called "Se vetëm zemra flet saktë" (Because only the heart speaks right) which speaks against adolescent gender violence, produced and penned by Rona herself. The song is part of a wide public awareness campaign led by the Kosovo Gender Studies Centre. It was supported and financed by the European Union.
On 18 September 2014, Rona Nishliu held a concert in Belgrade, Serbia to promote the Kosovar culture, part of the "Mirëdita, dobar dan" festival. She received a standing ovation from the public.
From 2017 she was a coach on The Voice of Albania 6 on Top Channel.
In Albania, Kosovo, Macedonia, and Montenegro, she is known as a pop singer/musician. The audience in Pristina and Tirana know her also as an experimental jazz singer. Her interpretation is characterized with nuances of soul music influences as well. Her vocal range and interpretative power are her strongest points.
Nishliu is depicted for her humanitarian spirit, taking part in numerous humanitarian concerts for the people in the need. While being a student, she organized few Humanitarian Concerts, including the one entitled to help displaced Kosovo Albanian families of Mitrovica living in poverty. In 2009 she took place as a guest lecturer in UNDP Kosovo's activity on Awareness Raising on the Importance of Volunteerism for the Youngsters in Vushtrri. She is an activist of the National Association of Autism in Kosovo, she is also a Chairperson of the Institute for Sustainability and Development of Youth in Kosovo."Flakaresha" (with Vesa Luma and Teuta Kurti)
"Të Lashë" (I left you)
"Shenja" (The sign)
"Veriu" (The North)
"A ka arsye (Ft. Bim Bimma)" (Is there any reason?)
"Shko pastro pas saj" (Go after her)
"Zonja Vdekje" (Mrs. Death)
"Se Vetëm Zemra Flet Saktë" (Because the heart speaks right)
Eurovision Song Contest 2012
Festivali i Këngës
Poli Fest Awards
Video Fest Awards