ATC code none PubChem CID 5074 ChemSpider 4896 Molar mass 477.569 g/mol | CAS Number 87051-43-2 IUPHAR/BPS 97 UNII 145TFV465S | |
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Medical vocabulary what does ritanserin mean
Ritanserin (INN, USAN, BAN) is a serotonin receptor antagonist which was never marketed for clinical use but has been used in scientific research.
Contents
- Medical vocabulary what does ritanserin mean
- How to pronounce ritanserin
- Research
- Pharmacology
- References
How to pronounce ritanserin
Research
Ritanserin was tested in clinical trials for schizophrenia and migraine.
Pharmacology
Ritanserin acts as a selective 5-HT2A (Ki = 0.45 nM) and 5-HT2C receptor (Ki = 0.71 nM) antagonist. It has relatively low affinity for the H1, D2, α1-adrenergic, and α2-adrenergic receptors (39-, 77-, 107-, and 166-fold lower relative to 5-HT2A, respectively). The affinity of ritanserin for the 5-HT1A receptor is than 1 µM. In addition to its affinity for the 5-HT2A and 5-HT2C receptors, ritanserin also binds to and antagonizes the 5-HT1D, 5-HT2B, 5-HT5A, 5-HT6, and 5-HT7 receptors.
The atypical antipsychotic risperidone was developed from ritanserin.