ATC code none PubChem CID 5074 ChemSpider 4896 Molar mass 477.569 g/mol | CAS Number 87051-43-2 IUPHAR/BPS 97 UNII 145TFV465S | |
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Medical vocabulary what does ritanserin mean
Ritanserin (INN, USAN, BAN) is a serotonin receptor antagonist which was never marketed for clinical use but has been used in scientific research.
Contents
How to pronounce ritanserin
Research
Ritanserin was tested in clinical trials for schizophrenia and migraine.
Pharmacology
Ritanserin acts as a selective 5-HT2A (Ki = 0.45 nM) and 5-HT2C receptor (Ki = 0.71 nM) antagonist. It has relatively low affinity for the H1, D2, α1-adrenergic, and α2-adrenergic receptors (39-, 77-, 107-, and 166-fold lower relative to 5-HT2A, respectively). The affinity of ritanserin for the 5-HT1A receptor is than 1 µM. In addition to its affinity for the 5-HT2A and 5-HT2C receptors, ritanserin also binds to and antagonizes the 5-HT1D, 5-HT2B, 5-HT5A, 5-HT6, and 5-HT7 receptors.
The atypical antipsychotic risperidone was developed from ritanserin.