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Rhazinilam is an alkaloid first isolated in 1965 by Linde from the Melodinus australis plant. It was later isolated from Rhazya stricta as well as from other sources.
Contents
Biological activity
Rhazinilam has activity similar to that of colchicine, taxol and vinblastine, acting as an inhibitor of the tubulin-microtubules equilibrium.
Total synthesis
Rhazinilam was first synthesized in 1973 by Smith and coworkers, and multiple subsequent times.
Trauner synthesis
Rhazinilam was synthesized by the Trauner group in 2005.
References
Rhazinilam Wikipedia(Text) CC BY-SA