Ravi Iyengar, is a systems biologist and principal investigator of the NIGMS-funded Systems Biology Center New York at The Mount Sinai Medical Center.
Trained as a biochemist, Iyengar studies cellular signaling networks using both experiments and computer simulations. His laboratory focuses on how cell signals are routed and processed through cellular signaling networks within cells to discover new drug targets for complex diseases. He has published more than 100 primary papers, 92 reviews and is the editor of 6 books.
Iyengar earned both an undergraduate degree in Chemistry and Physics in 1971 and a master's degree in Biophysics in 1973 from the University of Mumbai in India. He completed his Ph.D. in Biophysical Sciences at the University of Houston in 1977. He joined Baylor College of Medicine in 1977 as a postdoctoral fellow and rose to assistant and then associate professor. In 1986, he joined the Department of Pharmacology at The Mount Sinai Medical Center as an associate professor. In 1999, he was appointed chairman of the Department of Pharmacology at Mount Sinai, and in 2001 he was named Mount Sinai's Dorothy H. and Lewis Rosenstiel Professor and chair of the Department of Pharmacology and Biological Chemistry. He stepped down from his position as chair in January 2014.
Iyengar served as the dean of research for The Mount Sinai School of Medicine from 2002 to 2004.
In 2004, Iyengar was elected fellow of the American Association for the Advancement of Science. Additional honors include:
Established Investigator, American Heart Association, 1980–1983
New Investigator Award, NIH, 1978–1980
National Research Service Award, NIH
Iyengar holds Patent No. 20080261820: Methods to Analyze Biological Networks.
Structure and Function of Signal Transducing Components, 5R01DK03876-21, National Institute of Diabetes and Digestive and Kidney Diseases
Dynamics Underlying Tissue Integrity, 1R01DK087650-01, National Institute of Diabetes and Digestive Diseases and Kidney Diseases
Systems Biology Center in New York, 5P50GM071558-03, National Institute of General Medical Sciences
Functions of Regulatory Motifs in Signaling Networks, 5R01GM054508-21, National Institute of General Medical Sciences
Modeling Cell Regulatory Networks, 5R01GM072853-04, National Institute of General Medical Sciences
Heterotrimeric G Proteins, Volume 237 (Methods in Enzymology). John N. Abelson, Melvin I. Simon, Ravi Iyengar, editors. Academic Press; 1st edition (June 28, 1994) ISBN 0-12-182138-2
Heterotrimeric G-Protein Effectors, Volume 238 (Methods in Enzymology). John N. Abelson, Melvin I. Simon, Ravi Iyengar, Editors. Academic Press; 1st Edition (September 1994) ISBN 0-12-182139-0
G Protein Pathways, Part A: Receptors, Volume 343 (Methods in Enzymology). Ravi Iyengar, John D. Hildebrandt, Editors. Academic Press; 1st Edition (October 2001) ISBN 0-12-182244-3
G Protein Pathways, Part B: G Proteins and Their Regulators, Volume 344 (Methods in Enzymology). Ravi Iyengar, John D. Hildebrandt, Editors. Academic Press; 1st Edition (December 2001) ISBN 0-12-182245-1
G Protein Pathways, Part C: Effector Mechanisms, Volume 345 (Methods in Enzymology). Ravi Ravi Iyengar, John D. Hildebrandt, Editors. Academic Press; 1st Edition (October 2001) ISBN 0-12-182246-X
Partial list:
Ram, P. T.; Horvath, C. M.; Iyengar, R (2000). "Stat3-mediated transformation of NIH-3T3 cells by the constitutively active Q205L Galphao protein". Science. 287 (5450): 142–4. PMID 10615050. doi:10.1126/science.287.5450.142.
Jordan, J. D.; Landau, E. M.; Iyengar, R (2000). "Signaling networks: The origins of cellular multitasking". Cell. 103 (2): 193–200. PMC 3619409 . PMID 11057893. doi:10.1016/s0092-8674(00)00112-4.
Bhalla, U. S.; Ram, P. T.; Iyengar, R (2002). "MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network". Science. 297 (5583): 1018–23. PMID 12169734. doi:10.1126/science.1068873.
Jordan, J. D.; He, J. C.; Eungdamrong, N. J.; Gomes, I; Ali, W; Nguyen, T; Bivona, T. G.; Philips, M. R.; Devi, L. A.; Iyengar, R (2005). "Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through G(alpha)o/i-triggered proteasomal degradation of Rap1GAPII". Journal of Biological Chemistry. 280 (12): 11413–21. PMID 15657046. doi:10.1074/jbc.M411521200.
Ma'Ayan, A; Blitzer, R. D.; Iyengar, R (2005). "Toward predictive models of mammalian cells". Annual Review of Biophysics and Biomolecular Structure. 34: 319–49. PMC 3035045 . PMID 15869393. doi:10.1146/annurev.biophys.34.040204.144415.
Ma'Ayan, A; Jenkins, S. L.; Neves, S; Hasseldine, A; Grace, E; Dubin-Thaler, B; Eungdamrong, N. J.; Weng, G; Ram, P. T.; Rice, J. J.; Kershenbaum, A; Stolovitzky, G. A.; Blitzer, R. D.; Iyengar, R (2005). "Formation of regulatory patterns during signal propagation in a Mammalian cellular network". Science. 309 (5737): 1078–83. PMC 3032439 . PMID 16099987. doi:10.1126/science.1108876.
Moriarty, T. M.; Sealfon, S. C.; Carty, D. J.; Roberts, J. L.; Iyengar, R; Landau, E. M. (1989). "Coupling of exogenous receptors to phospholipase C in Xenopus oocytes through pertussis toxin-sensitive and -insensitive pathways. Cross-talk through heterotrimeric G-proteins". The Journal of Biological Chemistry. 264 (23): 13524–30. PMID 2474532.
Eungdamrong, N. J.; Iyengar, R (2007). "Compartment-specific feedback loop and regulated trafficking can result in sustained activation of Ras at the Golgi". Biophysical Journal. 92 (3): 808–15. PMC 1779960 . PMID 17098795. doi:10.1529/biophysj.106.093104.
Zaidel-Bar, R; Itzkovitz, S; Ma'Ayan, A; Iyengar, R; Geiger, B (2007). "Functional atlas of the integrin adhesome". Nature Cell Biology. 9 (8): 858–67. PMC 2735470 . PMID 17671451. doi:10.1038/ncb0807-858.
Lipshtat, A; Purushothaman, S. P.; Iyengar, R; Ma'Ayan, A (2008). "Functions of bifans in context of multiple regulatory motifs in signaling networks". Biophysical Journal. 94 (7): 2566–79. PMC 2267139 . PMID 18178648. doi:10.1529/biophysj.107.116673.
Bromberg, K. D.; Ma'Ayan, A; Neves, S. R.; Iyengar, R (2008). "Design logic of a cannabinoid receptor signaling network that triggers neurite outgrowth". Science. 320 (5878): 903–9. PMC 2776723 . PMID 18487186. doi:10.1126/science.1152662.
Neves, S. R.; Tsokas, P; Sarkar, A; Grace, E. A.; Rangamani, P; Taubenfeld, S. M.; Alberini, C. M.; Schaff, J. C.; Blitzer, R. D.; Moraru, I. I.; Iyengar, R (2008). "Cell shape and negative links in regulatory motifs together control spatial information flow in signaling networks". Cell. 133 (4): 666–80. PMC 2728678 . PMID 18485874. doi:10.1016/j.cell.2008.04.025.
Bhalla, U. S.; Iyengar, R (1999). "Emergent properties of networks of biological signaling pathways". Science. 283 (5400): 381–7. PMID 9888852. doi:10.1126/science.283.5400.381.
Weng, G; Bhalla, U. S.; Iyengar, R (1999). "Complexity in biological signaling systems". Science. 284 (5411): 92–6. PMC 3773983 . PMID 10102825. doi:10.1126/science.284.5411.92.
Jordan, J. D.; Carey, K. D.; Stork, P. J.; Iyengar, R (1999). "Modulation of rap activity by direct interaction of Galpha(o) with Rap1 GTPase-activating protein". The Journal of Biological Chemistry. 274 (31): 21507–10. PMID 10419452. doi:10.1074/jbc.274.31.21507.
Ram, P. T.; Horvath, C. M.; Iyengar, R (2000). "Stat3-mediated transformation of NIH-3T3 cells by the constitutively active Q205L Galphao protein". Science. 287 (5450): 142–4. PMID 10615050. doi:10.1126/science.287.5450.142.
Lipshtat, A; Jayaraman, G; He, J. C.; Iyengar, R (2010). "Design of versatile biochemical switches that respond to amplitude, duration, and spatial cues". Proceedings of the National Academy of Sciences. 107 (3): 1247–52. PMC 2824311 . PMID 20080566. doi:10.1073/pnas.0908647107.
Berger, S. I.; Iyengar, R (2011). "Role of systems pharmacology in understanding drug adverse events". Wiley Interdisciplinary Reviews: Systems Biology and Medicine. 3 (2): 129–35. PMC 3057924 . PMID 20803507. doi:10.1002/wsbm.114.
Rangamani, P; Fardin, M. A.; Xiong, Y; Lipshtat, A; Rossier, O; Sheetz, M. P.; Iyengar, R (2011). "Signaling network triggers and membrane physical properties control the actin cytoskeleton-driven isotropic phase of cell spreading". Biophysical Journal. 100 (4): 845–57. PMC 3037558 . PMID 21320428. doi:10.1016/j.bpj.2010.12.3732.
Xiong, Y; Rangamani, P; Fardin, M. A.; Lipshtat, A; Dubin-Thaler, B; Rossier, O; Sheetz, M. P.; Iyengar, R (2010). "Mechanisms controlling cell size and shape during isotropic cell spreading". Biophysical Journal. 98 (10): 2136–46. PMC 2872297 . PMID 20483321. doi:10.1016/j.bpj.2010.01.059.
Berger, S. I.; Ma'Ayan, A; Iyengar, R (2010). "Systems pharmacology of arrhythmias". Science Signaling. 3 (118): ra30. PMC 3068558 . PMID 20407125. doi:10.1126/scisignal.2000723.
Zorina, Y; Iyengar, R; Bromberg, K. D. (2010). "Cannabinoid 1 receptor and interleukin-6 receptor together induce integration of protein kinase and transcription factor signaling to trigger neurite outgrowth". Journal of Biological Chemistry. 285 (2): 1358–70. PMC 2801262 . PMID 19861414. doi:10.1074/jbc.M109.049841.
Lipshtat, A; Jayaraman, G; He, J. C.; Iyengar, R (2010). "Design of versatile biochemical switches that respond to amplitude, duration, and spatial cues". Proceedings of the National Academy of Sciences. 107 (3): 1247–52. PMC 2824311 . PMID 20080566. doi:10.1073/pnas.0908647107.
Berger, S. I.; Iyengar, R (2009). "Network analyses in systems pharmacology". Bioinformatics. 25 (19): 2466–72. PMC 2752618 . PMID 19648136. doi:10.1093/bioinformatics/btp465.
Neves, S. R.; Iyengar, R (2009). "Models of spatially restricted biochemical reaction systems". Journal of Biological Chemistry. 284 (9): 5445–9. PMC 2645809 . PMID 18940805. doi:10.1074/jbc.R800058200.
Ma'Ayan, A; Cecchi, G. A.; Wagner, J; Rao, A. R.; Iyengar, R; Stolovitzky, G (2008). "Ordered cyclic motifs contribute to dynamic stability in biological and engineered networks". Proceedings of the National Academy of Sciences. 105 (49): 19235–40. PMC 2614745 . PMID 19033453. doi:10.1073/pnas.0805344105.
Bromberg, K. D.; Ma'Ayan, A; Neves, S. R.; Iyengar, R (2008). "Design logic of a cannabinoid receptor signaling network that triggers neurite outgrowth". Science. 320 (5878): 903–9. PMC 2776723 . PMID 18487186. doi:10.1126/science.1152662.
Neves, S. R.; Tsokas, P; Sarkar, A; Grace, E. A.; Rangamani, P; Taubenfeld, S. M.; Alberini, C. M.; Schaff, J. C.; Blitzer, R. D.; Moraru, I. I.; Iyengar, R (2008). "Cell shape and negative links in regulatory motifs together control spatial information flow in signaling networks". Cell. 133 (4): 666–80. PMC 2728678 . PMID 18485874. doi:10.1016/j.cell.2008.04.025.
Lipshtat, A; Purushothaman, S. P.; Iyengar, R; Ma'Ayan, A (2008). "Functions of bifans in context of multiple regulatory motifs in signaling networks". Biophysical Journal. 94 (7): 2566–79. PMC 2267139 . PMID 18178648. doi:10.1529/biophysj.107.116673.
Zaidel-Bar, R; Itzkovitz, S; Ma'Ayan, A; Iyengar, R; Geiger, B (2007). "Functional atlas of the integrin adhesome". Nature Cell Biology. 9 (8): 858–67. PMC 2735470 . PMID 17671451. doi:10.1038/ncb0807-858.
Ma'Ayan, A; Jenkins, S. L.; Goldfarb, J; Iyengar, R (2007). "Network analysis of FDA approved drugs and their targets". Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine. 74 (1): 27–32. PMC 2561141 . PMID 17516560. doi:10.1002/msj.20002.
Eungdamrong, N. J.; Iyengar, R (2007). "Compartment-specific feedback loop and regulated trafficking can result in sustained activation of Ras at the Golgi". Biophysical Journal. 92 (3): 808–15. PMC 1779960 . PMID 17098795. doi:10.1529/biophysj.106.093104.
Ma'Ayan, A; Lipshtat, A; Iyengar, R (2006). "Topology of resultant networks shaped by evolutionary pressure". Physical Review E. 73 (6 Pt 1): 061912. PMC 3032447 . PMID 16906869. doi:10.1103/PhysRevE.73.061912.
Ma'Ayan, A; Jenkins, S. L.; Neves, S; Hasseldine, A; Grace, E; Dubin-Thaler, B; Eungdamrong, N. J.; Weng, G; Ram, P. T.; Rice, J. J.; Kershenbaum, A; Stolovitzky, G. A.; Blitzer, R. D.; Iyengar, R (2005). "Formation of regulatory patterns during signal propagation in a Mammalian cellular network". Science. 309 (5737): 1078–83. PMC 3032439 . PMID 16099987. doi:10.1126/science.1108876.
Ma'Ayan, A; Blitzer, R. D.; Iyengar, R (2005). "Toward predictive models of mammalian cells". Annual Review of Biophysics and Biomolecular Structure. 34: 319–49. PMC 3035045 . PMID 15869393. doi:10.1146/annurev.biophys.34.040204.144415.
Jordan, J. D.; He, J. C.; Eungdamrong, N. J.; Gomes, I; Ali, W; Nguyen, T; Bivona, T. G.; Philips, M. R.; Devi, L. A.; Iyengar, R (2005). "Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through G(alpha)o/i-triggered proteasomal degradation of Rap1GAPII". Journal of Biological Chemistry. 280 (12): 11413–21. PMID 15657046. doi:10.1074/jbc.M411521200.
Neves, S. R.; Ram, P. T.; Iyengar, R (2002). "G protein pathways". Science. 296 (5573): 1636–9. PMID 12040175. doi:10.1126/science.1071550.
