ATC code None PubChem CID 5745207 ChEMBL CHEMBL2107771 Molar mass 302.343 g/mol | CAS Number 133865-88-0 ChemSpider 4676525 ECHA InfoCard 100.120.272 | |
 | ||
Ralfinamide (INN) (code names NW-1029, FCE-26742A, PNU-0154339E) is a multimodal drug which is under investigation by Newron Pharmaceuticals for the treatment of neuropathic pain and other pain conditions such as post-operative dental pain.
It has a relatively complex pharmacology, acting as a mixed voltage-gated sodium channel blocker (including Nav1.7), N-type calcium channel blocker, noncompetitive NMDA receptor antagonist, and monoamine oxidase B inhibitor.
It has thus far progressed as far as phase IIb/phase III clinical trials. In 2010 it failed a phase II trial for lower back pain. Encouraging Phase II results have been announced for neuropathic pain.
References
Ralfinamide Wikipedia(Text) CC BY-SA