Entrez 50484 | Ensembl ENSG00000048392 | |
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Aliases RRM2B, MTDPS8A, MTDPS8B, P53R2, ribonucleotide reductase regulatory TP53 inducible subunit M2B External IDs MGI: 2155865 HomoloGene: 56723 GeneCards: RRM2B | ||
Ribonucleoside-diphosphate reductase subunit M2 B is an enzyme that in humans is encoded by the RRM2B gene. The gene encoding the RRM2B protein is located on chromosome 8, at position 8q23.1. The gene and its products are also known by designations MTDPS8A, MTDPS8B, and p53R2.
Contents
Interactions
RRM2B has been shown to interact with Mdm2 and Ataxia telangiectasia mutated.
Clinical relevance
Mutations in this gene have been shown to cause progressive external ophthalmoplegia. Increased expression of RRM2B has been correlated with gemcitabine resistance in human cholangiocarcinoma cells and may be predictive of lack of clinical benefit from gemcitabine for human cancers.
References
RRM2B Wikipedia(Text) CC BY-SA