An RPG maker is a game creation system (software program) intended to make it easy for non-programmers to create a role-playing game. The target audience for most of these products is artists and creative types who have the imaginative abilities to assemble the elements of a game (artwork, plotline, music, etc.) but lack the technical skill to program it themselves.
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RPG Maker
The most famous RPG maker is the commercial Japanese RPG Maker series that has been released since 1988 for many systems ranging from the PC-8801, MSX, PC-9801, and Microsoft Windows, to the Super Famicom, PlayStation, Game Boy Color, PlayStation 2, and Cellphones.
Other RPG makers
While not an RPG maker per se, the Worldforge game engine is intended for creating MMORPGs.
References
RPG creation software Wikipedia(Text) CC BY-SA