Species Human Entrez 9810 | Human Mouse Ensembl ENSG00000103549 | |
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Aliases RNF40, BRE1B, RBP95, STARING, ring finger protein 40 External IDs MGI: 2142048 HomoloGene: 8856 GeneCards: RNF40 | ||
E3 ubiquitin-protein ligase BRE1B is an enzyme that in humans is encoded by the RNF40 gene.
Contents
Function
The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery.
Interactions
RNF40 has been shown to interact with STX1A.
References
RNF40 Wikipedia(Text) CC BY-SA