Species Human Entrez 51132 | Human Mouse Ensembl ENSG00000131263 | |
Aliases RLIM, NY-REN-43, RNF12, ring finger protein, LIM domain interacting External IDs MGI: 1342291 HomoloGene: 7920 GeneCards: RLIM | ||
E3 ubiquitin-protein ligase RLIM is an enzyme that in humans is encoded by the RLIM gene.
Contents
Function
The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be a ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Alternatively spliced transcript variants encoding the same protein have been reported. Functions in female mice as a regulator of X chromosome inactivation .
Interactions
RNF12 has been shown to interact with Estrogen receptor alpha.
References
RNF12 Wikipedia(Text) CC BY-SA