Entrez 54778 | Ensembl ENSG00000157450 | |
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Aliases RNF111, ARK, ring finger protein 111 External IDs MGI: 1934919 HomoloGene: 9741 GeneCards: RNF111 | ||
E3 ubiquitin-protein ligase Arkadia is an enzyme that in humans is encoded by the RNF111 gene.
Contents
Function
The protein encoded by this gene contains a RING finger domain, a motif known to be involved in protein-protein and protein-DNA interactions. The mouse counterpart of this gene (Rnf111/arkadia) has been shown to genetically interact with the transforming growth factor (TGF) beta-like factor Nodal, and act as a modulator of the nodal signaling cascade, which is essential for the induction of mesoderm during embryonic development.
Interactions
RNF111 has been shown to interact with Mothers against decapentaplegic homolog 7 and Mothers against decapentaplegic homolog 3.
References
RNF111 Wikipedia(Text) CC BY-SA