Species Human Entrez 80010 | Human Mouse Ensembl ENSG00000178966 | |
 | ||
Aliases RMI1, BLAP75, C9orf76, FAAP75, RecQ mediated genome instability 1 External IDs MGI: 1921636 HomoloGene: 41601 GeneCards: RMI1 | ||
RecQ-mediated genome instability protein 1 is a protein that in humans is encoded by the RMI1 gene.
Meiosis
During meiosis in budding yeast Saccharomyces cerevisiae, TOP3 (a type I topoisomerase) and its accessory factor RMI1 form a heterodimer that functions to allow passage of one DNA single strand through another. The TOP3-RMI1 heterodimer associates with Sgs1 (Bloom helicase ortholog) to form a complex that catalyzes dissolution of double Holliday junctions. Furthermore, the TOP3-RMI1 heterodimer participates in all meiotic recombination functions associated with Sgs1, most significantly as an early recombination intermediate chaperone, promoting regulated crossover and non-crossover recombination and preventing accumulation of aberrant recombination intermediates. In particular, the TOP3-RMI1–SGS1 complex promotes early formation of non-crossover recombinants during meiosis.