Aliases RHOBTB3 Ensembl ENSG00000164292 | Entrez 22836 | |
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External IDs MGI: 1920546 HomoloGene: 8932 GeneCards: RHOBTB3 | ||
Rho-related BTB domain-containing protein 3 is a protein that in humans is encoded by the RHOBTB3 gene.
Contents
Function
RHOBTB3 is a member of the evolutionarily conserved RhoBTB subfamily of Rho GTPases. For background information on RHOBTBs, see RHOBTB1 (MIM 607351).[supplied by OMIM]
Model organisms
Model organisms have been used in the study of RHOBTB3 function. A conditional knockout mouse line, called Rhobtb3tm1a(KOMP)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty three tests were carried out on mutant mice and four significant abnormalities were observed. Homozygote mutant males had a decreased body weight and abnormal tooth morphology; females had decreased forepaw grip strength and both sexes had a decreased body length.