Species Human Entrez 64407 | Human Mouse Ensembl ENSG00000150681 | |
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Aliases RGS18, RGS13, regulator of G-protein signaling 18 External IDs MGI: 1927498 HomoloGene: 11281 GeneCards: RGS18 | ||
Regulator of G-protein signaling 18 is a protein that in humans is encoded by the RGS18 gene.
Contents
Function
This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Interactions
RGS18 has been shown to interact with GNAI3.