Species Human Entrez 5947 | Human Mouse Ensembl ENSG00000114115 | |
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Aliases RBP1, CRABP-I, CRBP, CCRBPI, RBPC, retinol binding protein 1 External IDs MGI: 97876 HomoloGene: 2175 GeneCards: RBP1 | ||
Retinol binding protein 1, cellular, also known as RBP1, is a protein that in humans is encoded by the RBP1 gene.
Contents
Function
RBP1 is the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. The gene harbors four exons encoding 24, 59, 33, and 16 amino acid residues, respectively. The second intervening sequence alone occupies 19 kb of the 21 kb of the gene.
Clinical significance
Cellular retinol-binding protein-1 (CRBP-1) contributes to the maintenance of the differentiative state of endometrial cells through the regulation of bioavailability of retinol. On the converse, loss of CRBP-1 is associated with development of endometrial cancer.