Species Human Entrez 5930 | Human Mouse Ensembl ENSG00000122257 | |
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Aliases RBBP6, MY038, P2P-R, PACT, RBQ-1, SNAMA, retinoblastoma binding protein 6, RB binding protein 6, ubiquitin ligase External IDs MGI: 894835 HomoloGene: 136812 GeneCards: RBBP6 | ||
Retinoblastoma-binding protein 6 is a protein that in humans is encoded by the RBBP6 gene.
Contents
Function
The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene.
Interactions
RBBP6 has been shown to interact with Y box binding protein 1.
References
RBBP6 Wikipedia(Text) CC BY-SA