Species Human Entrez 11186 | Human Mouse Ensembl ENSG00000068028 | |
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Aliases RASSF1, 123F2, NORE2A, RASSF1A, RDA32, REH3P21, Ras association domain family member 1 External IDs MGI: 1928386 HomoloGene: 10499 GeneCards: RASSF1 | ||
Ras association domain-containing protein 1 is a protein that in humans is encoded by the RASSF1 gene.
Contents
Function
This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Seven alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Interactions
RASSF1 has been shown to interact with: