Species Human Entrez 5886 | Human Mouse Ensembl ENSG00000179262 | |
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Aliases RAD23A, HHR23A, HR23A, RAD23 homolog A, nucleotide excision repair protein External IDs MGI: 105126 HomoloGene: 48322 GeneCards: RAD23A | ||
UV excision repair protein RAD23 homolog A is a protein that in humans is encoded by the RAD23A gene.
Contents
Function
The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair (NER). This protein was shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, as well as with ubiquitin protein ligase E6AP, and thus suggests that this protein may be involved in the ubiquitin mediated proteolytic pathway in cells.
Interactions
RAD23A has been shown to interact with: