Entrez 29127 | Ensembl ENSG00000161800 | |
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Aliases RACGAP1, CYK4, HsCYK-4, ID-GAP, MgcRacGAP, Rac GTPase activating protein 1 External IDs MGI: 1349423 HomoloGene: 8077 GeneCards: RACGAP1 | ||
Function
Rho GTPases control a variety of cellular processes. There are 3 subtypes of Rho GTPases in the Ras superfamily of small G proteins: RHO (see MIM 165370), RAC (see RAC1; MIM 602048), and CDC42 (MIM 116952). GTPase-activating proteins (GAPs) bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, Rho GAPs negatively regulate Rho-mediated signals. GAPs may also serve as effector molecules and play a role in signaling downstream of Rho and other Ras-like GTPases.[supplied by OMIM]
Interactions
RACGAP1 has been shown to interact with Rnd2 and SLC26A8.
During cytokinesis, RACGAP1 has been shown to interact with KIF23 to form the centralspindlin complex. This complex is essential for the formation of the central spindle. RACGAP1 also interacts with PRC1 to stabilize and maintain the central spindle as anaphase proceeds.