Trade names Accupril MedlinePlus a692026 Routes ofadministration Oral Molar mass 438.516 g/mol Protein binding 97% | AHFS/Drugs.com Monograph Pregnancycategory D ATC code C09AA06 (WHO) CAS ID 85441-61-8 | |
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How to pronounce quinapril accupril memorizing pharmacology flashcard
Quinapril (marketed under the brand name Accupril by Pfizer) is an angiotensin-converting enzyme inhibitor (ACE inhibitor) used in the treatment of hypertension and congestive heart failure. A prodrug, it is converted to its active metabolite, quinaprilat, in the liver.
Contents
- How to pronounce quinapril accupril memorizing pharmacology flashcard
- Mechanism of action
- Indications
- Contraindications
- Side effects
- References
Mechanism of action
Quinapril inhibits angiotensin converting enzyme, an enzyme which catalyses the formation of angiotensin II from its precursor, angiotensin I. Angiotensin II is a powerful vasoconstrictor and increases blood pressure through a variety of mechanisms. Due to reduced angiotensin production, plasma concentrations of aldosterone are also reduced, resulting in increased excretion of sodium in the urine and increased concentrations of potassium in the blood.
Indications
Quinapril is indicated for the treatment of high blood pressure (hypertension) and as adjunctive therapy in the management of heart failure. It may be used for the treatment of hypertension by itself or in combination with thiazide diuretics, and with diuretics and digoxin for heart failure.
Contraindications
Side effects
Side effects of quinapril include dizziness, cough, vomiting, upset stomach, angioedema, and fatigue.