Trisha Shetty (Editor)

Queuine

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Formula
  
C12H15N5O3

Molar mass
  
277.28 g/mol

Queuine httpsuploadwikimediaorgwikipediacommonsthu

Gene music using protein sequence of qtrt1 queuine trna ribosyltransferase 1


Queuine (Q) is a hypermodified nucleobase found in the first (or wobble) position of the anticodon of tRNAs specific for Asn, Asp, His, and Tyr, in most eukaryotes and prokaryotes.

Contents

The nucleoside of queuine is queuosine. Queuine is not found in the tRNA of archaea; however, a related 7-deazaguanine derivative, the nucleoside of which is archaeosine, occurs in different tRNA position, the dihydrouridine loop, and in tRNAs with more specificities.

What does queuine mean


Literature

  • Walter R. Farkas: „Queuine, The Q-Containing tRNAs and the Enzymes Responsible for Their Formation“, Nucleosides, Nucleotides & Nucleic Acids, 1983, 2 (1), pp. 1–20 (doi:10.1080/07328318308078845).
  • Hiroshi Akimoto, Eiko Imamiya, Takenori Hitaka, Hiroaki Nomura, Susumu Nishimura: „Synthesis of Queuine, the Base of Naturally Occurring Hypermodified Nucleoside (Queuosine), and Its Analogues“, J. Chem. Soc., Perkin Trans. 1, 1988, pp. 1637–1644 (doi:10.1039/P19880001637).
  • Charles J. Barnett, Lana M. Grubb: „Total Synthesis of Q-Base (Queuine)“, Tetrahedron, 2000, 56 (47), pp. 9221–9225 (doi:10.1016/S0040-4020(00)00895-4).
  • Florian Klepper: Synthese der natürlichen tRNA Nukleosidmodifikationen Queuosin und Archaeosin, Dissertation, München 2007 (PDF; 5,1 MB), pp. 25–28.
  • Allen F. Brooks, George A. Garcia, H. D. Hollis Showalter: „A Short, Concise Synthesis of Queuine“, Tetrahedron Letters, 2010, 51 (32), pp. 4163–4165 (doi:10.1016/j.tetlet.2010.06.008; PDF).

    • References

    Queuine Wikipedia
    (Text) CC BY-SA


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