Girish Mahajan (Editor)

Pyrimidine analogue

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Pyrimidine analogue

Pyrimidine analogues are nucleoside analog antimetabolites which mimic the structure of metabolic pyrimidines.

Contents

Examples

  • 5-Fluorouracil (5FU) which inhibits thymidylate synthase.
  • Floxuridine (FUDR)
  • Cytarabine (Cytosine arabinoside)
  • 6-azauracil (6-AU)

    • Medical Uses

    Pyrimidine antimetabolites are commonly used to treat cancer by interfering with DNA replication.

    References

    Pyrimidine analogue Wikipedia
    (Text) CC BY-SA


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