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Pukateine

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ATC code
  
none

PubChem CID
  
442340

3D model (Jmol)
  
Interactive image

Pubchem
  
442340

ChemSpider ID
  
390793

CAS Number
  
81-67-4

Formula
  
C18H17NO3

Molar mass
  
295.332 g/mol

ChEMBL ID
  
258370

Pukateine httpsuploadwikimediaorgwikipediacommonsee

Synonyms
  
(R)-11-hydroxy-1,2-methylenedioxyaporphine

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Pukateine is an alkaloid found in the bark of the New Zealand tree Laurelia novae-zelandiae ("Pukatea"). An extract from pukatea is used in traditional Māori herbal medicine as an analgesic, and it is thought pukateine is the active component, as it is similar in both structure and activity to alkaloids such as glaucine and tetrahydropalmatine which are found in Chinese medicinal herbs used as analgesics. Pukateine has multiple mechanisms of action, with the most prominent effects being as an agonist at the D2 dopamine receptor and antagonist at the α1-adrenergic receptor.

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Bernard Cracroft Aston studied the physical and chemical characteristics of the compound, and presented a paper with his findings to the Royal Society of New Zealand on May 11, 1909.

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References

Pukateine Wikipedia