EC number 2.3.2.13 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 80146-85-6 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, a protein-glutamine gamma-glutamyltransferase (EC 2.3.2.13) is an enzyme that catalyzes the chemical reaction
Contents
protein glutamine + alkylamineThus, the two substrates of this enzyme are protein glutamine and alkylamine, whereas its two products are protein N(5)-alkylglutamine and NH3.
This enzyme participates in complement and coagulation cascades and Huntington's disease. It employs one cofactor, calcium.
Nomenclature
This enzyme belongs to the family of transferases, specifically the aminoacyltransferases. The systematic name of this enzyme class is protein-glutamine:amine gamma-glutamyltransferase. Other names in common use include:
Structural studies
As of late 2007, 19 structures have been solved for this class of enzymes, with PDB accession codes 1EVU, 1EX0, 1F13, 1FIE, 1G0D, 1GGT, 1GGU, 1GGY, 1IU4, 1KV3, 1L9M, 1L9N, 1NUD, 1NUF, 1NUG, 1QRK, 1RLE, 1SGX, and 1VJJ.