ATC code G03DB07 (WHO) CAS Number 34184-77-5 KEGG D08431 Formula C22H30O2 Pubchem 36709 | Synonyms R-5020; RU-5020 PubChem CID 36709 ECHA InfoCard 100.207.681 Molar mass 326.47 g/mol ChemSpider ID 33716 | |
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Medical vocabulary what does promegestone mean
Promegestone (INN) (brand name Surgestone), also known as 17α,21-dimethyl-Δ9-19-norprogesterone or 17α,21-dimethyl-19-norpregna-4,9-diene-3,20-dione, is a steroidal progestin of the 19-norprogesterone group which was introduced in 1983 and is marketed in France, Portugal, and Argentina. Indications include gynaecological conditions caused by luteal insufficiency, including premenopausal disorders, dysmenorrhea, and premenstrual syndrome. Promegestone has weak glucocorticoid activity, but does not bind to the androgen receptor or possess antimineralocorticoid activity. In addition, promegestone has been found to act as a non-competitive antagonist of the nicotinic acetylcholine receptor, similarly to progesterone. The drug is mainly bound to albumin; it does not bind to sex hormone-binding globulin, and binds only weakly to transcortin.