Population Health Research Institute

Updated on Oct 31, 2023

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Established 1992 (1992) Field of research Epidemiology Date founded 1992 Field of research Epidemiology		Research type Clinical Province Ontario Director Salim Yusuf

Location Hamilton, Ontario, Canada Campus Hamilton General Hospital Affiliations McMaster University McMaster University Medical School

The Population Health Research Institute (PHRI), is a population health research institute located at McMaster University Medical School. It was founded in 1992 by Salim Yusuf as a preventative cardiology and therapeutics research program and has emerged as a world leading research institute specializing in epidemiological research, population health and randomized clinical trials.

Research

The PHRI has led multinational trials that have achieved widespread acclaim and influenced medical regulations and approvals around the world. Some of the biggest multinational trials ever published were published at the PHRI including:

HOPE - Demonstrated the effectiveness of the ACE inhibitor ramipril in secondary prevention of heart disease - NEJM 2000

INTERHEART - Demonstrated the same 9 risk factors (smoking, lipids, hypertension, diabetes, obesity, diet, physical activity, alcohol consumption, and psychosocial factors) were a significant cause of heart attacks across the world, all ethnic groups and both genders - Lancet 2004

CURE - Demonstrated that anti-platelet drug clopidogrel with aspirin was superior to placebo with aspirin for patients presenting with NSTEMI - NEJM 2001

HOPE-3 - Demonstrated that rousuvastatin significantly lowered rates of stroke, myocardial infarction and death from cardiovascular causes in intermediate risk patients without cardiovascular disease - NEJM 2016

Researchers

Salim Yusuf

Richard Whitlock

References

Population Health Research Institute Wikipedia

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Research

Researchers

References