Girish Mahajan (Editor)

Poorly differentiated thyroid cancer

Updated on
Edit
Like
Comment
Share on FacebookTweet on TwitterShare on LinkedInShare on Reddit
Specialty
  
oncology

ICD-9-CM
  
193

MeSH
  
D013964

ICD-10
  
C73

eMedicine
  
med/

Poorly differentiated thyroid carcinoma (PDTC) is malignant neoplasm of follicular cell origin showing intermediate histopathological patterns between differentiated and undifferentiated thyroid cancers.

Contents

Histopathological features

  • Presence of small cells with round nuclei and scant cytoplasm with a diffuse solid pattern
  • Round or oval nests (insulae) or in trabeculae.
  • Solid growth and presence of microfollicles, some of which contain dense colloid.
  • Extrathyroidal extension and blood vessel invasion
  • Foci of necrosis,
  • Larger than 5 cm in greatest diameter at diagnosis
  • Clinical features

  • PDTC affects predominantly females about 55 years of age
  • Both local and distant (lung, bone, brain)
  • References

    Poorly differentiated thyroid cancer Wikipedia