Aliases PIGR, Pigr Ensembl ENSG00000162896 | Entrez 5284 | |
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External IDs MGI: 103080 HomoloGene: 1984 GeneCards: PIGR | ||
Polymeric immunoglobulin receptor (pIgR) is a protein that in humans is encoded by the PIGR gene. It is a Fc receptor which facilitates the secretion of the soluble polymeric isoforms of immunoglobulin A and immunoglobulin M.
Contents
Function
pIgR is expressed on several glandular epithelia including those of liver and breast. It mediates transcellular transport of polymeric immunoglobulin molecules. It is a member of the immunoglobulin superfamily.
Structure
The receptor has five domians with homology to the immunoglobulin fold plus a transmembrane region, which also has some homology to certain immunoglobulin variable regions.
References
Polymeric immunoglobulin receptor Wikipedia(Text) CC BY-SA