Species Human Entrez 25945 | Human Mouse Ensembl ENSG00000177707 | |
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Aliases NECTIN3, CD113, CDW113, NECTIN-3, PPR3, PRR3, PVRR3, PVRL3, nectin cell adhesion molecule 3 External IDs MGI: 1930171 HomoloGene: 9162 GeneCards: NECTIN3 | ||
Poliovirus receptor-related 3 (PVRL3), also known as nectin-3 and CD113, is a human protein of the immunoglobulin superfamily which forms part of adherens junctions.
Contents
Function
Nectins (e.g., PVRL1; MIM 600644) are immunoglobulin-like adhesion molecules that interact with afadin (AF6; MIM 159559). Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton. The nectin-afadin system organizes adherens junctions cooperatively with the cadherin (see MIM 192090)-catenin (see MIM 116805) system in epithelial cells.[supplied by OMIM]
Interactions
PVRL3 has been shown to interact with:
References
Poliovirus receptor-related 3 Wikipedia(Text) CC BY-SA