Plouffe is a French surname. People with the surname include:
David Plouffe (born 1967), American campaign managerKatherine and Michelle Plouffe (born 1992), Canadian basketball players and twin sistersSimon Plouffe (born 1956), Quebec mathematicianSteve Plouffe (born 1975), Canadian retired ice hockey goaltenderTrevor Plouffe (born 1986), American baseball playerLa Famille Plouffe, Quebec TV series of the 1950s (and revived in the 1980s)