Plouffe is a French surname. People with the surname include:
David Plouffe (born 1967), American campaign manager
Katherine and Michelle Plouffe (born 1992), Canadian basketball players and twin sisters
Simon Plouffe (born 1956), Quebec mathematician
Steve Plouffe (born 1975), Canadian retired ice hockey goaltender
Trevor Plouffe (born 1986), American baseball player
La Famille Plouffe, Quebec TV series of the 1950s (and revived in the 1980s)
