Plotkin (Russian: Плоткин) is a surname of Russian origin, which means a person from Płotki. It may refer to:
Andrew Plotkin (born 1970), American writer
Brian Plotkin (born 1984), American soccer player
Chuck Plotkin, American record producer
Diana Plotkin, American political activist
Eugene Plotkin (mathematician) (born 1955), Israeli mathematician
Eugene Plotkin (banker) (born 1980), American banker and criminal
Faith Plotkin (born 1947), American writer
Gordon Plotkin (born 1946), British computer scientist
Hal Plotkin (born 1957), American journalist and public servant
James Plotkin (born 1970), American guitarist
Mark Plotkin (born 1955), American botanist
Stanley Plotkin (born 1930), American physician
Tom Plotkin, American actor
