Formula C22H34O5 | Molar mass 378.502 g/mol | |
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How to pronounce pleuromutilin
Pleuromutilin and its derivatives are antibacterial drugs that inhibit protein synthesis in bacteria by binding to the peptidyl transferase component of the 50S subunit of ribosomes.
Contents
This class of antibiotics includes the licensed drugs retapamulin (approved for topical use in humans), valnemulin and tiamulin (approved for use in animals) and the investigational drugs azamulin and lefamulin (BC-3781).
How to pronounce pleuromutilins
History
Pleuromutilin was first discovered as an antibiotic in 1950. It is derived from the fungus Clitopilus passeckerianus (formerly Pleurotus passeckerianus), and has also been found in Drosophila subatrata, Clitopilus scyphoides, and some other Clitopilus species.
References
Pleuromutilin Wikipedia(Text) CC BY-SA