Girish Mahajan (Editor)

Pidilizumab

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Type
  
Whole antibody

Target
  
PD-1

CAS Number
  
1036730-42-3

Source
  
Humanized (from mouse)

ATC code
  
none

ChemSpider
  
none

Pidilizumab (formerly CT-011) is a monoclonal antibody being developed by Medivation for the treatment of cancer and infectious diseases. Pidilizumab was originally thought to bind to the PD-1 immune checkpoint molecule, but this is currently uncertain. Pidilizumab causes in the attenuation of apoptotic processes in lymphocytes, primarily effector/memory T cells.

Clinical trials

It had encouraging results by 2011 from phase II clinical trials for diffuse large B-cell lymphoma. A phase II open-label study in combination for relapsed follicular lymphoma found good results compared to usual response rates. An add-on trial for multiple myeloma is ongoing.

References

Pidilizumab Wikipedia


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