EC number 3.6.1.31 ExPASy NiceZyme view | CAS number 69553-55-5 | |
In enzymology, a phosphoribosyl-ATP diphosphatase (EC 3.6.1.31) is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are 1-(5-phosphoribosyl)-ATP and H2O, whereas its two products are 1-(5-phosphoribosyl)-AMP and diphosphate.
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is 1-(5-phosphoribosyl)-ATP diphosphohydrolase. Other names in common use include phosphoribosyl-ATP pyrophosphatase, and phosphoribosyladenosine triphosphate pyrophosphatase. This enzyme participates in histidine metabolism. It employs one cofactor, H+.
Structural studies
As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1Y6X, 1YVW, 1YXB, and 2A7W.