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Phosphonoacetate hydrolase

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EC number
  
3.11.1.2

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

CAS number
  
153570-68-4

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

Phosphonoacetate hydrolase

In enzymology, a phosphonoacetate hydrolase (EC 3.11.1.2) is an enzyme that catalyzes the chemical reaction

phosphonoacetate + H2O acetate + phosphate

Thus, the two substrates of this enzyme are phosphonoacetate and H2O, whereas its two products are acetate and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on carbon-phosphorus bonds. The systematic name of this enzyme class is phosphonoacetate phosphonohydrolase. This enzyme participates in aminophosphonate metabolism. It employs one cofactor, zinc.

Structural studies

The structure of this enzyme, with the PDB accession code 1EI6, shows it adopts the alkaline phosphatase fold.

References

Phosphonoacetate hydrolase Wikipedia