Puneet Varma (Editor)

Phospholipase D1

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Aliases
  
PLD1

Human
  
Mouse

Ensembl
  
ENSG00000075651

Species
  
Human

Entrez
  
5337

Phospholipase D1

External IDs
  
MGI: 109585 HomoloGene: 116234 GeneCards: PLD1

Phospholipase D1 is an enzyme that in humans is encoded by the PLD1 gene.

Contents

Function

Phosphatidylcholine (PC)-specific phospholipases D (PLDs) EC 3.1.4.4 catalyze the hydrolysis of PC to produce phosphatidic acid and choline. A range of agonists acting through G protein-coupled receptors and receptor tyrosine kinases stimulate this hydrolysis. PC-specific PLD activity has been implicated in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis (Hammond et al., 1995).[supplied by OMIM]

Interactions

Phospholipase D1 has been shown to interact with:

Inhibitors

  • VU-0359595: 1,700-fold selective versus phospholipase D2, IC50 = 3.7nM.

    • References

    Phospholipase D1 Wikipedia
    (Text) CC BY-SA


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