Phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase

In enzymology, a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase (EC 3.1.3.67) is an enzyme that catalyzes the chemical reaction

phosphatidylinositol 3,4,5-trisphosphate + H₂O ⇌ phosphatidylinositol 4,5-bisphosphate + phosphate

Thus, the two substrates of this enzyme are phosphatidylinositol 3,4,5-trisphosphate and H₂O, whereas its two products are phosphatidylinositol 4,5-bisphosphate and phosphate.

This enzyme class belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is 1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 3-phosphohydrolase. Other names in common use include PTEN, MMAC1, and phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase. PTEN also refers to a member of the class, phosphatase and tensin homolog. This enzyme class participates in 10 metabolic pathways: inositol phosphate metabolism, phosphatidylinositol signaling system, p53 signaling pathway, focal adhesion, tight junction, endometrial cancer, glioma, prostate cancer, melanoma, and small cell lung cancer. It employs one cofactor, magnesium.