Group Group I (dsDNA) Family Podoviridae Rank Genus | Order Caudovirales Subfamily Autographivirinae | |
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Phikmvlikevirus is a genus of viruses that infect bacteria. There are currently four species in this genus including the type species Pseudomonas phage phiKMV. Bacteriophage phiKMV and its relatives are known to be highly virulent phages, producing large (3–15 mm (0.12–0.59 in) diameter) clear plaques on a susceptible host. The only reported exception is phage LKA1, which yields small plaques (1 mm (0.039 in)) surrounded by a halo. While all other P. aeruginosa-specific phikmvlikeviruses use the Type IV pili as primary receptor, LKA1 particles attach to the bacterial lipopolysaccharide layer.
Contents
Taxonomy
Group: dsDNA
Virology
Electron microscopic imaging of purified phage particles revealed these phages as typical members of the Podoviridae, with a head diameter of approximately 60 nm (2.4×10−6 in) and a stubby tail with a length of 8–10 nm. Although phiKMV phage resembles the well-studied podovirus T7 in overall genome architecture, it was the first known T7-like phage which encoded a single-subunit RNA polymerase gene downstream its DNA metabolism genes instead of in the early genomic region. Based on these properties, the genus Phikmvlikevirus is classified within the Autographivirinae.
Life Cycle
Viral replication is cytoplasmic. Entry into the host cell is achieved by adsorption into the host cell. DNA-templated transcription is the method of transcription. The virus exits the host cell by lysis, and holin/endolysin/spanin proteins. Bacteria serve as the natural host. Transmission routes are passive diffusion.