Peptidyl glutaminase

In enzymology, a peptidyl-glutaminase (EC 3.5.1.43) is an enzyme that catalyzes the chemical reaction

Thus, the two substrates of this enzyme are alpha-N-peptidyl-L-glutamine and H₂O, whereas its two products are alpha-N-peptidyl-L-glutamate and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is peptidyl-L-glutamine amidohydrolase. Other names in common use include peptidoglutaminase I, peptideglutaminase, and peptidoglutaminase.