Crayton was born in Rockdale, Texas. He began playing guitar seriously after moving to California in 1935, later settling in San Francisco. While there he absorbed the music of T-Bone Walker but developed his own unique approach. His aggressive playing contrasted with his smooth vocal style and was copied by many later blues guitarists.
He went on to record for many other record labels in the 1950s, including Imperial in New Orleans, Vee-Jay in Chicago and Jamie in Philadelphia. It is thought he was the first blues guitarist to use a Fender Stratocaster, playing an instrument given to him by Leo Fender. His album Things I Used to Do was released by Vanguard Records in 1971. He continued to tour and record in the following years.
A longtime resident of Los Angeles, California, Crayton died there of a heart attack in 1985. He was interred in the Inglewood Park Cemetery.
10" Shellac (78-rpm) and 7" vinyl (45-rpm) records
"After Hours' Boogie" / "Why Did You Go", Four Star 1304 (1947, released 1949)
"Don't Ever Fall in Love" / "Pee Wee Special", Gru-V-Tone 217 (1947, released 1949)
"Blues After Hours" / "I'm Still in Love with You", Modern 20-624 (1948)
"Texas Hop" / "Central Avenue Blues", Modern 20-643 (1948)
"Boogie Woogie Basement" / "Boogie Woogie Upstairs", billed as Al "Cake" Wichard Trio Featuring Pee Wee Crayton on Guitar, Modern 20-657 (1949)
"When Darkness Falls" / "Rock Island Blues", Modern 20-658 (1949)
"The Bop Hop" / "I Love You So", Modern 20-675 (1949)
"Long After Hours" / "Brand New Woman", Modern 20-707 (1949)
"Old Fashioned Baby" / "Bounce Pee Wee", Modern 20-719 (1949)
"Please Come Back" / "Rockin' the Blues", Modern 20-732 (1950)
"Some Rainy Day" / "Huckle Boogie", Modern 20-742 (1950)
"Answer to Blues After Hours" / "Louella Brown", Modern 20-763 (1950)
"Good Little Woman" / "Dedicating the Blues", Modern 20-774 (1950)
"Change Your Way of Lovin'" / "Tired of Travelin'", Modern 20-796 (1951)
"Poppa Stoppa" / "Thinkin' of You", Modern 20-816 (1951)
"When It Rains, It Pours" / "Daybreak", Aladdin 3112 (1951)
"Cool Evening" / "Have You Lost Your Love for Me" Modern 20-892 (1952)
"Pappy's Blues" / "Crying and Walking", RIH (Recorded in Hollywood) 408 (1953)
"Baby, Pat the Floor" / "I'm Your Prisoner", RIH (Recorded in Hollywood) 426 (1953)
"Steppin' Out" / "Hey Little Dreamboat", Hollywood 1055 (1953)
"Do Unto Others" / "Every Dog Has His Day", Imperial 5288 (1954)
"Wino-O" / "Hurry, Hurry", Imperial 5297 (1954)
"I Need Your Love" / "You Know, Yeah", Imperial 5321 (1954)
"My Idea About You" / "I Got News for You", Imperial 5338 (1955)
"Eyes Full of Tears" / "Runnin' Wild", Imperial 5345 (1954, released 1955)
Great Rhythm & Blues Oldies, Volume 5: Pee Wee Crayton, Blues Spectrum (Johnny Otis's label) LP BS-105 (1974)
Everyday I Have the Blues, Big Joe Turner with Crayton and Sonny Stitt, Pablo LP 2310-818 (1978)
Have No Fear Joe Turner Is Here, Big Joe Turner and Crayton, Pablo LP 2310-863 (1981)
Peace of Mind, Charly R&B LP CFM-601 (1982), 10" vinyl LP containing all 10 tracks that Crayton recorded for Vee Jay Records in 1956–1957
Blues Guitar Genius: Pee Wee Crayton, Volume 1, Ace LP CH-23 (1982), 10" vinyl LP containing tracks recorded for Modern Records, 1949–1952
Rocking Down on Central Avenue: Pee Wee Crayton, Volume Two, Ace LP CHA-61 (1982), tracks recorded for Modern Records.
Make Room for Pee Wee, Murray Brothers LP MB-1005 (recorded August 1983)
Early Hour Blues, Murray Brothers LP MB-1007 (recorded December 1984)
Pee Wee Crayton: Memorial Album, Ace LP CHD-177 (1986), tracks recorded for Modern Records
After Hours Boogie: Pee Wee Crayton and His Guitar, Blues Boy LP BB-307 (1988), tracks recorded from 1947 to 1962 for numerous labels, with Crayton's first demo recording, "Pee Wee's Hop" (1945), a piano–guitar–bass instrumental
Pee Wee's Blues: The Complete Aladdin and Imperial Recordings, Capitol-EMI 36292 (1996)
Blues After Hours: The Essential Pee Wee Crayton, Blues Encore 52045 (1996), recordings made for numerous labels, 1947–1956
The Modern Legacy, Volume 1, Ace CHD-632 (1996)
Early Hour Blues, Blind Pig 5052 (1999), CD containing both Murray Brothers albums
Blues Guitar Magic: The Modern Legacy, Volume 2, Ace CHD-767 (2000)
Blues After Hours: The Essential Pee Wee Crayton, Indigo 2526 (2002), tracks recorded for Modern Records, 1948–1951
Texas Blues Jumpin' in Los Angeles: The Modern Music Sessions 1948–1951, Ace CHD-1400 (2014)