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Paul Lieberman

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Name
  
Paul Lieberman


Role
  
Researcher

Paul Lieberman httpswwwwistarorgsitesdefaultfilesscienti

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Paul M. Lieberman, Ph.D., is a researcher and director of the Center for Chemical Biology and Translational Medicine at The Wistar Institute in Philadelphia. He is also the Hilary Koprowski, M.D., Endowed Professor, the McNeil Professor of Molecular Medicine and Translational Research, a professor in the Gene Expression and Regulation Program, and the Scientific Director of the Protein Expression and Libraries Facility at Wistar. Lieberman's research focus is how certain viruses are linked to cancer, particularly Epstein-Barr virus.

Contents

Lieberman and his laboratory collaborated with Memorial Sloan-Kettering Cancer Center to develop the first annotated atlas of the genome of Epstein-Barr virus. In 2011, Liberman received a Seeding Drug Discovery Award from Wellcome Trust for $4.7 million to develop a drug against Epstein-Barr virus-related cancers. This was the first project to receive such an award from the United Kingdom-based trust. Lieberman serves as the president of the International Association for Research on Epstein-Barr virus and Associated Diseases.

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Select publications

  • Deng Z, Glousker G, et al., Lieberman PM, Tzfati, Y. Inherited mutations in the helicase RTEL1 cause telomere dysfunction and Hoyeraal-Hreidarsson syndrome. PNAS 2013.
  • Dheekollu J, Chen HS, Kaye KM, Lieberman PM. Timeless-dependent DNA replication-coupled recombination promotes Kaposi’s Sarcoma-associated herpesvirus episome maintenance and terminal repeat stability. J. Virology. 2013 Apr 87(7):369.
  • Deng Z, Wang Z, Stong N, Plasschaert R, et al. Riethman H, and Lieberman PM. A role for CTCF and cohesion in subtelomere chromatin organization, TERRA transcription, and telomere end protection. EMBO J. 2012 Nov 31(21):4165.
  • Kang H, Cho H, Sung GH, Lieberman PM. CTCF regulates Kaposi’s sarcoma-associated herpesvirus latency transcription by nucleosome displacement and RNA polymerase programming. Journal of Virology 2013 Feb 87(3)1789.
  • Arvey A, Tempera I, Tsai K, Chen HS, Tikhmyanova N, Klichinsky M, Leslie C, Lieberman PM. An atlas of the Epstein-Barr virus transcriptome and epigenome reveals host-virus regulatory interactions. Cell Host Microbe 2012 Aug 12(2)233.

    • References

    Paul Lieberman Wikipedia
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